5-Amino-1MQ 5mg

5-Amino-1MQ 5mg

5-Amino-1MQ is a small molecule NNMT inhibitor. Unlike most compounds in the research space, it’s not a peptide it’s a methylquinolinium that blocks nicotinamide N-methyltransferase, an enzyme heavily expressed in fat tissue.

What the Research Covers

NNMT consumes NAD+ precursors and regulates how efficiently fat cells store energy. Inhibiting it shifts that balance. Research has focused on:

• Adipocyte metabolism. Studies in obese mouse models showed reduced fat cell size and lower body weight without changes to food intake.
• NAD+ levels. Blocking NNMT preserves nicotinamide, which feeds back into NAD+ synthesis. Downstream effects on sirtuin activity are a common research angle.
• Energy expenditure. Research has measured increased metabolic rate in fat tissue rather than appetite suppression.
• Muscle tissue. NNMT expression rises with age in skeletal muscle. Some studies have looked at inhibition and muscle regeneration in aged models.
• Metabolic markers. Insulin sensitivity and glucose handling appear across the metabolic literature.

The distinction worth noting: this works on how fat cells behave, not on appetite or thermogenic stimulation.

Specifications

Reconstitution

Mix with bacteriostatic water. Common ratios:

• 5 mg + 1 mL = 5 mg/mL. A 0.1 mL draw = 0.5 mg
• 5 mg + 2 mL = 2.5 mg/mL. A 0.2 mL draw = 0.5 mg

Add the water slowly down the vial wall. Do not shake. Store refrigerated after mixing and use within 30 days. Keep out of direct light.